bochureIFSC_family_22[1].pdf
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On Thu, 28 Apr 2022, 6:05 am CHIFA - Child Health and Rights, <
CHIFA@dgroups.org> wrote:
> CHIFA - Child Health and Rights
>
> *Summary for April 27*
>
> - Neonatal sepsis and mortality in LMICs
> <#m_-6646300524870305788_m_-3305169605769789777_m_-4920434887678974233_m_-4521676586146881115_dfpa8kn3> 1
> message
>
> Neonatal sepsis and mortality in LMICs
> <https://dgroups.org/groups/chifa/discussions/dfpa8kn3>
>
> Neil Pakenham-Walsh
> April 27
>
>
> A large multicentre study in The Lancet Global Health. Citation, summary
> and a comment from me below.
>
> CITATION: Neonatal sepsis and mortality in low-income and middle-income
> countries from a facility-based birth cohort: an international multisite
> prospective observational study.
> Rebecca Milton et al.
> Lancet Global Health, volume 10, issue 5, e661-e672, may 01, 2022
> Published: May, 2022 DOI: https://doi.org/10.1016/S2214-109X(22)00043-2
>
> SUMMARY
> Background: Neonatal sepsis is a primary cause of neonatal mortality and
> is an urgent global health concern, especially within low-income and
> middle-income countries (LMICs), where 99% of global neonatal mortality
> occurs. The aims of this study were to determine the incidence and
> associations with neonatal sepsis and all-cause mortality in facility-born
> neonates in LMICs.
>
> Methods: The Burden of Antibiotic Resistance in Neonates from Developing
> Societies (BARNARDS) study recruited mothers and their neonates into a
> prospective observational cohort study across 12 clinical sites from
> Bangladesh, Ethiopia, India, Pakistan, Nigeria, Rwanda, and South Africa...
>
> Findings: Between Nov 12, 2015 and Feb 1, 2018, 29 483 mothers and 30 557
> neonates were enrolled. The incidence of clinically suspected sepsis was
> 166·0 (95% CI 97·69–234·24) per 1000 livebirths, laboratory-confirmed
> sepsis was 46·9 (19·04–74·79) per 1000 livebirths, and all-cause mortality
> was 0·83 (0·37–2·00) per 1000 neonate-days. Maternal hypertension, previous
> maternal hospitalisation within 12 months, average or higher monthly
> household income, ward size (>11 beds), ward type (neonatal), living in a
> rural environment, preterm birth, perinatal asphyxia, and multiple births
> were associated with an increased risk of clinically suspected sepsis,
> laboratory-confirmed sepsis, and all-cause mortality. The majority (881
> [72·5%] of 1215) of laboratory-confirmed sepsis cases occurred within the
> first 3 days of life.
>
> Interpretation: Findings from this study highlight the substantial
> proportion of neonates who develop neonatal sepsis, and the high mortality
> rates among neonates with sepsis in LMICs. More efficient and effective
> identification of neonatal sepsis is needed to target interventions to
> reduce its incidence and subsequent mortality in LMICs.
>
> COMMENT (NPW): It would be interesting also to understand quality-of-care
> factors, including the extent to which healthcare providers are empowered
> to deliver the care for which they are trained.
>
> Neil Pakenham-Walsh, Global Coordinator HIFA, www.hifa.org neil@hifa.org
> Reply
> <CHIFA@dgroups.org?subject=Re:%20Neonatal+sepsis+and+mortality+in+LMICs>
>
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